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Laboratory References
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Laboratory References
Dr. Lynn Averill, M.D. PhD
With a very broad scientific and medical background in Immunopathology, Dr. Averill earned her PhD in Immunopathology at the University of Washington, Seattle, WA. Her thesis work centered on elucidating the mechanisms of decline in the immune response with aging. Dr. Averill's postdoctoral studies at Case Western Reserve University, and at St. Vincent Charity Hospital in Cleveland, Ohio focused on delineating immune dysfunction in patients with autoimmune disease, infectious disease, and atherosclerosis. She then went on to earn a MD at Saba University School of Medicine, Netherlands, Antilles and to complete the residency training requirements in Clinical Pathology at the University of Hawaii, Honolulu, HI. Subsequently, Dr. Averill completed a Fellowship in
Immunopathology at UT Southwestern Medical Center, Dallas, TX. Dr. Averill's research centered on immune dysfunction in patients with chronic Hepatitis C Viral Infection.
INTRODUCTION
It makes sense to do laboratory Allergy testing that is both specific and comprehensive, testing for the patient IgG and IgE immune response to food/mold and/ or inhalant allergens for the following reasons:
The immunoglobulins IgG and IgE are integral parts of the Immune System, Keyword "System" and, while they appear to function independently; like the fingers of the hand, they are part of a whole and, function interdependently.
The listed references are key clinical papers which address specific topics on Allergy and are from respected scientific journals, most notably, the Journal of Allergy and Clinical Immunology.
The doctors at Immuno Laboratories have reviewed and discussed these papers at length and have concluded that there is great benefit to both IgG and IgE Allergy testing.
The listed articles link food/mold and or inhalant sensitivities to diseases including; excema, atopic dermatitis, celiac disease, rheumatoid arthritis, irritable bowel syndrome, chronic urticaria, leaky gut syndrome, autism, and many more.
Many of these diseases and conditions are not simply mediated by IgG or IgE alone-there may be components of both making up the immune response while one or the other may predominate.
This is why it is important to convey the "big picture" to the physicians
To test for one without testing the other would be like a partial physical examination.
Most importantly, we should remind physicians that the patient's disease or condition may be caused by food or other allergy. A physician should keep this in mind in their differential diagnosis, since allergy is often overlooked, and may be the "hidden cause" of the patient's illness after all other avenues have been checked.
Please visit our Physicians Forum to discuss these articles or share knowledge on related topics.
A CASE FOR THE ROLE OF IGG SUBCLASS ANTIBODIES IN ALLERGY
Total IgG, rather than measurement of a single subclass (IgG4), is a more sensitive indicator of a patients' reactivity to a specific food or environmental inhalant. Although IgG4 may be elevated in response to some allergens, measurement of this subclass alone will not adequately reflect a patient's sensitivity to the broad array of allergens tested. As summarized in the articles listed below the other IgG subclasses (IgG1, IgG2, and IgG3) have all been found to contribute to a patients' allergic response to a wide array of food and environmental allergens.
The role of IgG Subclass Antibodies in Allergic Reactions
Serum levels of IgG subclasses in relation to IgE and atopic disease in early infancy
Cord blood levels of IgG subclass antibodies to food and inhalant allergens in relation to maternal atopy and the development of atopic disease during the first 8 years of life
The relationships among shrimp-specific IgG subclass antibodies and immediate adverse reactions to shrimp challenge
Serum IgG subclass antibodies to a variety of food antigens in patients with celiac disease
Sub-class of IgG I allergic disease. I. IgG sub-class antibodies in immediate and non-immediate food allergy
ARTHRITIS AND ALLERGY
Gut Joint Axis
AUTISM AND ALLERGY
Food and Autism
Milk and Autism
CELIAC DISEASE AND ALLERGY
Celiac Disease
CANDIDA ALBICANS AND LEAKY GUT SYNDROME
Food Allergies and Candida Albicans
CORTISOL AND ALLERGY
Cortisol
FAMILY HISTORY AND AGE WITH RESPECT TO FOOD ALLERGY
Age and Immune Response to Food Antigens
Family History and Cord Blood IgG to Food and InhalantsFOOD ALLERGY - GENERAL ARTICLES
Food Allergy-Self Reported
Update on Food AllergyHelicobacter pylori-and Gastrointestinal disease
A bacterium that causes chronic gastritis, duodenitis and gastric cancer
A historical perspective of Helicobacter gastroduodenitis and its complications
Value of Quantitative Serology for Confirmation of Helicobacter pylori Eradication: An 18 month Follow-Up Study
Diagnosis of Helicobacter pylori: Invasive and non-invasive tests
Helicobacter pylori and Probiotics
Diet, H pylori infection and gastric cancer: Evidence and controversies
Update on Helicobacter pylori Treatment
Lifestyle-Related Diseases and Helicobacter pylori Infection
Helicobacter pylori Detection and Antimicrobial Susceptibility TestingIgG SUBCLASSES AND IgE IN ALLERGIC DISEASE
Relation of IgG and IgE Levels to Allergens
Serum Levels of IgG Subclasses in Relation to IgE and Atopic Disease
IRRITABLE BOWL SYNDROME AND ALLERGY
Alteration of Food-Antigen Specific Serum IgE and IgG in Irritable Bowel Syndrome and Functional Dyspepsia
Food Elimination Based on IgG Level in Irritable Bowel Syndrome
Intestinal Permeability and Chronic Urticaria and Arthritis
MULTIPLE SCLEROSIS AND FOOD SENSITIVITIES
Multiple Sclerosis and Food sensitivities
SPECIFIC FOOD ALLERGENS
Atopic Dermatitis and Wheat Allergens
Cow's Milk Allergy
IgG Level and Shrimp Allergy
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