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The role of IgG Subclass Antibodies in Allergic Reactions
Dr. Lynn Averill, MD, PhD
Nakagawa T. The role of IgG subclass antibodies in the clinical response to immunotherapy in allergic disease. Clin Exp Allergy. 1991 May;21(3):289-96. (Click here to view/order article at Pubmed) Dr. Averill
Patients with late asthmatic responses (LAR) to house dust mites show an elevated level of IgG1 subclass antibodies which may contribute to the pathogenesis of asthma. Immune complex mediated type III allergic reactions might be involved in the pathophysiological mechanism of the LAR
Immunotherapy to house dust mites elicited an increase in IgG4 antibodies which apparently correlated with effectiveness of treatment and may represent blocking antibodies
Egg allergic children possessed significantly higher IgG1 as compared with those without egg allergy at ages 6 to 10 years.
Our study suggests that IgG1 but not IgG4 antibodies may contribute to atopy and anaphylaxis reactions to egg and house dust mites
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