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Family History and Cord Blood IgG to Food and Inhalants
Dr. Lynn Averill, MD, PhD
Jenmalm MC, Björkstén B. Cord blood levels of immunoglobulin G subclass antibodies to food and inhalant allergens in relation to maternal atopy and the development of atopic disease during the first 8 years of life. Clin Exp Allergy. 2000 Jan;30(1):34-40. (Click here to view/order article at Pubmed) Dr. Averill:
Study suggests patients with a family history of allergy should be tested for food and inhalant allergens.
The results of this study suggest patients symptomatic for cat, mites, and inhalants showing low IgE levels should be tested for specific IgG levels as IgG rather than IgE may be elevated in these patients.
The levels of food and inhalant allergen-specific IgG antibodies of most subclasses were higher in cord serum from infants of atopic mothers, as compared with babies of nonatopic mothers. This was most obvious for the IgG4 subclass.
It has been reported the levels of IgG and IgG4 antibodies to Mites are higher in atopic individuals while the IgG1 antibody are similar to those found in nonatopic individuals.
Grass pollen-specific IgG4 antibody titres are higher in atopic than nonatopic individuals.
Higher IgG4 binding to cat dander has also been reported in atopic as compared with nonatopic individuals.
IgG1 and IgG4 are higher in birch pollen allergic than in normal individuals.Dr. Bennett:
Rationale for testing mother and child with family history for IgG food and inhalant allergies.
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