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IgG Level and Shrimp Allergy
Dr. Lynn Averill, MD, PhD
Morgan JE, Daul CB, Lehrer SB. The relationships among shrimp-specific IgG subclass antibodies and immediate adverse reactions to shrimp challenge. J Allergy Clin Immunol. 1990 Sep;86(3 Pt 1):387-92. (Click here to view/order article at Pubmed) Dr. Averill:
High levels of shrimp-specific IgE in association with a positive prick test are not always predictive of a positive immediate response to double blind placebo controlled food challenge with shrimp.
The observation that shrimp-sensitive individuals in general have increased levels of circulating shrimp-specific IgG is of interest because antigen/allergen specific IgG subclasses have been associated with adverse reactions to foods.
Individuals with a history of shrimp sensitivity had significantly raised shrimp-specific IgG2 and IgG4 compared to shrimp-tolerant individuals. There is a positive correlation with shrimp-specific IgG and IgE levels.Dr. Bennett:
Rationale for IgG and IgE food allergy testing for patients with known adverse shrimp reaction.
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