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HOME | Laboratory References | Intestinal Permeability and Chronic . . .
 

Intestinal Permeability and Chronic Urticaria and Arthritis
Dr. Lynn Averill, MD, PhD

Paganelli R, Fagiolo U, Cancian M, Scala E. Intestinal permeability in patients with chronic urticaria-angioedema with and without arthralgia. Ann Allergy. 1991 Feb;66(2):181-4. (Click here to view/order article at Pubmed)

Dr. Averill:

  • Gut permeability to cow milk B-lactoglobulin (BLG) was significantly increased in patients with arthralgia and improved with an oligoantigenic diet.
  • Patients with high titers of IgG to BLG showed the highest absorption of BLG and the groups with arthralgia showed higher BLG levels than those without arthralgia
  • In all cases specific IgE to cow milk was absent
  • These data suggest that the symptoms of a subgroup of patients with chronic urticaria and especially patients with joint complaints that subside with diet are related to excess intestinal permeability.
  • Dietary manipulation has been found to improve symptoms in rheumatoid arthritis.
  • Recently food allergy has been confirmed as a cause for arthralgia in allergic patients who also suffered from asthma or rhinitis. The majority of them had specific IgE to egg or dairy products.

    Dr. Bennett:

  • Rationale for IgG food allergy testing for patients with hives, angioedema, and arthritis.


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