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Cortisol
Dr. Lynn Averill, MD, PhD
Ball TM, Anderson D, Minto J, Halonen M. Cortisol circadian rhythms and stress responses in infants at risk of allergic disease. J Allergy Clin Immunol. 2006 Feb;117(2):306-11. (Click here to view/order article at Pubmed) Dr. Averill:
Might want to analyze cortisol levels in patients with allergic disease compared to those without allergy to see if correlation in adult patients;
Suspect lower early am endogenous levels of cortisol to correlate with presence of allergic disease and asthma
The circadian rhythm of cortisol was flattened because of the lack of the expected morning surge of cortisol resulting in decreased diurnal variation of cortisol in infants of mothers with allergy or asthma.
The cortisol stress response was greater in infants of mothers with allergy or asthma, those with fewer siblings, and those not entering day care early in life.
The alterations in both basal and stress levels of endogenous cortisol among infants predisposed to allergic disease might affect the development of
allergic immune response early in life through interactions with inflammatory mediators.Dr. Bennett:
Rationale for testing food allergies, IgE and IgG based on low cortisol results in infants
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