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Total Immunoglobulin E
Immunoglobulins of the IgE class play an important role in mediating the atopic reactions that occur when sensitive individuals are exposed to allergens. In deciding on a course of therapy, it is important to distinguish between IgE-mediated and non-IgE mediated reactions. Measurement of the total circulating IgE level in a patient's serum by the two-step solid phase chemiluminescent immunoassay in conjunction with other supporting diagnostic information can aid in making this diagnosis. In general, the total IgE level increases with the number of allergies a person has and with the amount of exposure to relevant allergens. The finding of an elevated total IgE is an excellent screening assay and if elevated may justify testing for allergen-specific IgE in one of our Environmental & Food Allergy tests.